相同基因条件下牙周治疗与动脉硬化的相关性

doi:10.19439/j.sjos.2017.02.017

上海口腔医学 ›› 2017, Vol. 26 ›› Issue (2): 209-212.doi: 10.19439/j.sjos.2017.02.017

相同基因条件下牙周治疗与动脉硬化的相关性

韩亚琨, 林晓萍

中国医科大学附属盛京医院口腔科,辽宁沈阳 110004

收稿日期:2016-01-03 修回日期:2016-12-01 出版日期:2017-04-25 发布日期:2017-05-04
通讯作者: 林晓萍,E-mail:xiaoping_ba@126.com
作者简介:韩亚琨（1986-）,男,在读博士研究生,E-mail: 84665842@qq.com
基金资助:
吉林省教育厅十二五规划课题（GH14354）; 吉林市科技创新发展计划（201536110）

The relationship between periodontitis and arterial sclerosis without genetic confounding

HAN Ya-kun, LIN Xiao-ping

Department of Stomatology, Shengjing Hospital of China Medical University. Shenyang 110004, Liaoning Province, China

Received:2016-01-03 Revised:2016-12-01 Online:2017-04-25 Published:2017-05-04

摘要/Abstract

摘要： 目的: 探讨在排除基因差异后,牙周基础治疗对牙周病患者动脉硬化的影响,比较治疗前、后动脉硬化指标的改变,分析两者之间的关系。方法: 按一定标准选取2013年9月—2015年6月在门诊就诊的同卵双生双胞胎患者52对104例,其中24对48例为牙周健康患者,28对56例为牙周病患者。将每对双胞胎分配到不同组别中,即A组（24对48例牙周健康）、B组（28例牙周病）、C组（28例牙周病,基因型同B组）,C组为治疗组,A、B为对照组。检测术前、术后6周、12周患者血清C反应蛋白（CRP）、白细胞介素6（IL-6）、肿瘤坏死因子α（TNF-α）水平以及颈动脉内膜中层厚度（IMT）。采用SPSS17.0软件包对组间差异进行F检验。结果: 治疗前,牙周病组（B组和C组）各项指标均显著高于健康组（A组）;治疗后,A、B组各项指标无显著改变,C组各项指标均显著低于治疗前（P<0.05）。结论: 牙周病对动脉硬化有一定促进作用,且这种作用可独立于基因型作用而存在,积极的牙周治疗可在一定程度上阻止动脉硬化的发生与发展。

关键词: 基因型, 牙周病, 动脉硬化, 牙周基础治疗, 同卵双生双胞胎

Abstract: PURPOSES: The aim of this study was to evaluate periodontitis as a significant risk factor related to arterial sclerosis after eliminating genetic confounding. METHODS: Fifty two monozygotic twin pairs, 104 patients, were divided into 3 groups. group A: 24 pairs, 48 healthy people, as the blank group; group B: 28 patients with periodontitis, as the control group; group C: 28 patients with periodontitis, as the treatment group. The sample in group B and C had the same gene type. The index of CRP, IL-6, TNF-αand IMT were detected before treatment, 6 and 12 week after treatment. The data were analyzed using SPSS 17.0 software package. RESULTS: The index of CRP, IL-6, TNF-α and IMT decreased after treatment in group C, there was no significant change in group A and B at each check point. CONCLUSIONS: Periodontitis can promote the development of sclerosis without the intervening of gene.

Key words: Gene type, Periodontitis, Sclerosis, Periodontal treatment, Monozygotic twins

中图分类号:

R781.4

韩亚琨, 林晓萍. 相同基因条件下牙周治疗与动脉硬化的相关性[J]. 上海口腔医学, 2017, 26(2): 209-212.

HAN Ya-kun, LIN Xiao-ping. The relationship between periodontitis and arterial sclerosis without genetic confounding[J]. Shanghai Journal of Stomatology, 2017, 26(2): 209-212.

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相同基因条件下牙周治疗与动脉硬化的相关性

The relationship between periodontitis and arterial sclerosis without genetic confounding

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