The expression of VEGF-C in the condylar cartilage after anterior disc displacement and its clinical significance

Abstract

Abstract: PURPOSE: To investigate the expression and significance of vascular endothelial growth factor-C in the condylar cartilage after anterior disc displacement of temporomandibular joint. METHODS: Sixty healthy adult Japanese rabbits were used in this study. Forty-eight rabbits were subjected to surgical anterior disc displacement in the right TMJs, every 12 rabbits were sacrificed 1, 2, 4, 8 weeks post-operation, 12 rabbits without operation were used as normal control.The gene expression and distribution of VEGF-C in condylar cartilage were studied by gene chip, real-time quantitative PCR and SP immunohistochemical methods. Paired t test was used for analysis with SPSS19.0 software package. RESULTS: After anterior disc displacement, the expression of VEGF-C in the 2nd week reached to a minimum level, there was a significant difference (P<0.05), and increased in the 8th week. VEGF-C was expressed by cells of articular cartilage in the proliferative zone, hypertrophic zone and calcified cartilage zone. The expression in 1-week group was mainly found in the deep proliferative zone and hypertrophic zone, while the expression mainly found in the hypertrophic zone in 2-and 4-week group; calcified cartilage gradually enhanced, and there was significant difference (P<0.05) between 8-week group and control group. CONCLUSIONS: VEGF-C gene transcription and expression may be involved in the remodeling of the condylar cartilage after anterior disc displacement.

Key words: Anterior disc displacement, Mandibular condyle, VEGF-C , Gene chip

CLC Number:

R782.6

XU Gao-li,WANG Shu-hua,SHI Qiu-tao,LIU Yi,YAN Fan,XU Ting,GU Zhi-yuan. The expression of VEGF-C in the condylar cartilage after anterior disc displacement and its clinical significance[J]. Shanghai Journal of Stomatology, 2016, 25(2): 136-140.

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