The function of osteopontin and other cytokines in the diagnosis of SjÖgren’s syndrome

Shanghai Journal of Stomatology ›› 2013, Vol. 22 ›› Issue (3): 322-325.

• Clinical Study • Previous Articles Next Articles

The function of osteopontin and other cytokines in the diagnosis of SjÖgren’s syndrome

SUN Wei^1,2, YU Li², WEI Ben-juan², ZHOU Hai-wen¹

1.Department of Oral Mucosal Disease, Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Stomatology. Shanghai 200011;
2. Department of Stomatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200127, China

Received:2013-02-19 Revised:2013-04-15 Online:2013-06-10 Published:2013-06-10

Abstract

Abstract: PURPOSE: To explore the relationship of serum concentrations of osteopontin(OPN), TNF-α and TGF-β1 in SjÖgren’s syndrome patients. METHODS: Forty [SjÖgren’s] syndrome (SS) patients were determined by pathological examination, which included 15 primary SS and 25 secondary SS. Serum level of OPN, TNF-alpha and TGF-beta 1 were examined by enzyme linked immunosorbent assay (ELISA). Multiple correlation analysis was performed using SPSS13.0 software package. RESULTS: Serum OPN, TNF-alpha levels increased in SS compared with healthy subjects (P<0.05).Serum TGF-beta 1 level in secondary SS significantly increased than primary SS (P<0.05). On the contrary, serum TGF-beta1 level had no significant change compared with the controls. OPN was correlated with TGF-beta 1. CONCLUSIONS: OPN and TNF-alpha may be used as adjunctive diagnostic parameter. TGF-beta 1 can be used as an index in differential diagnosis of primary and secondary SS. OPN and TGF-beta 1 have different effects and interactions between them, demonstrating mutuality, diversity and integrity of the cytokine network.

Key words: SjÖgren’s syndrome, Osteopontin, Immunohistochemistry, ELISA

CLC Number:

R781.5

SUN Wei, YU Li, WEI Ben-juan, ZHOU Hai-wen. The function of osteopontin and other cytokines in the diagnosis of SjÖgren’s syndrome[J]. Shanghai Journal of Stomatology, 2013, 22(3): 322-325.

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The function of osteopontin and other cytokines in the diagnosis of SjÖgren’s syndrome

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