Expression and significance of BDNF and TrkB and E-cadherin in salivary adenoid cystic carcinoma

Abstract

Abstract: PURPOSE: To investigate the expression of brain-derived neurotrophic factor (BDNF), tropomysin-related kinase B (TrkB) and E-cadherin in salivary adenoid cystic carcinoma (SACC) and its correlation with clinicopathological characteristics. METHODS: BDNF, Trkb and E-cadherin expression in 76 primary SACC cases and 20 normal salivary gland tissues were analyzed by immunohistochemical staining. The results and clinicopathological data were statistically analyzed by SPSS17.0 software package with χ² test, Wilcoxon rank sum test, and Spearman’s rank correlation coefficient test. RESULTS: High expression of BDNF (89.5%) and TrkB (92.1%) and low expression of E-cadherin (46.1%) were found in SACC cases. The expression of BDNF was significantly associated with the clinical stages and distance metastasis (P<0.05). The expression of TrkB was significantly associated with the clinical stage, perineural invasion and distance metastasis (P<0.05). The expression of E-cadherin was significantly associated with the clinical stages, histopathological types, perineural invasion and distance metastasis (P<0.05). There was no significant correlation between the expression of BDNF and E-cadherin (P>0.05). However, the expression of TrkB was negatively correlated with the expression of E-cadherin (P<0.05). CONCLUSION: The expression of BDNF, TrkB and E-cadherin was closely correlated to the clinicopathological characteristics of SACC. The detection of BDNF, TrkB and E-cadherin expression may be of great significance for clinicopathological study and diagnosis of SACC.

Key words: BDNF, TrkB, E-cadherin, Salary gland, Adenoid cystic carcinoma, Tumor invasion, Tumor metastasis

CLC Number:

R739.8

WANG Wei-xi, YANG Xin-jie, JIA Sen, HU Zhi-qiang, WU Bao-lei, LEI De-lin. Expression and significance of BDNF and TrkB and E-cadherin in salivary adenoid cystic carcinoma[J]. China Journal of Oral and Maxillofacial Surgery, 2014, 12(4): 289-294.

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