Shanghai Journal of Stomatology ›› 2019, Vol. 28 ›› Issue (5): 460-466.doi: 10.19439/j.sjos.2019.05.003

• Original Articles • Previous Articles     Next Articles

Research of TC-PHBHHx/β-TCP compounds for treatment of dry socket in SD rats

SUN Xiao-juan1,2, LIU Ping-ping2, ZHOU Zhong-wei1,2, QIN Li-ye2, FU Hao2, ZHENG Lan-tian2, CAO Kun1,2   

  1. 1.General Hospital of Ningxia Medical University.Yinchuan 750004;
    2.Ningxia Medical University.Yinchuan 750004, Ningxia Hui Autonomous Region, China
  • Received:2018-07-19 Online:2019-10-25 Published:2019-12-11

Abstract: PURPOSE: The effects of different compounds on dry socket were evaluated in order to find a new method that can both be antibacterial and osteogenic,providing experimental evidence for future clinical application. METHODS: Seventy-two male SD rats, with upper left anterior teeth been extracted, were infected by pus to result in dry socket.Seven days later, they were allocated randomly and evenly into 4 groups and received different treatment, i.e. group A: debridement; group B: debridement and filled with iodoform gauzes; group C: debridement and filled with periocline; group D: debridement and filled with TC-PHBHHx/β-TCP. After being treated for 1,4,8 weeks, sequential fluorescent labeling was performed. The animals were sacrificed after the procedure and hard tissue and decalcified sections were harvested for histological and histomorphometrical evaluation. Statistical analysis was performed using SPSS 19.0 software package. RESULTS: At the same time point, the results of osteogenesis in group A, B and C were not significantly different while the results in group D was significantly different from other groups; accordingly, significant new bone formation was observed. At different observation time, the bone area in group B and C were not significant different over time. In group A, little new bone formation was found but surrounded by a large amount of inflammatory cells at 8 week. However, group D showed bone area increasing gradually with time. CONCLUSIONS: TC-PHBHHx/β-TCP has significant anti-inflammatory and osteogenic effects. Iodoform gauzes and periocline have good anti-inflammatory results but not significant osteogenic effects.

Key words: Dry socket, TC-PHBHHx/β-TCP;, Osteogenesis, Rat

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