上海口腔医学

上海口腔医学 ›› 2020, Vol. 29 ›› Issue (3): 293-297.doi: 10.19439/j.sjos.2020.03.012

• 论著 • 上一篇    下一篇

奥硝唑联合牙周组织再生术治疗牙周炎的有效性及安全性评价

王梦佳1, 达雨2, 郑丽纯3   

  1. 1.南京大学医学院附属口腔医院 口腔科,江苏 南京 210018;
    2.南京医科大学附属逸夫医院 口腔科,江苏 南京 210018;
    3.南京大学医学院附属口腔医院 预防科,江苏 南京 210018
  • 收稿日期:2019-09-16 修回日期:2019-11-13 出版日期:2020-06-25 发布日期:2020-07-29
  • 通讯作者: 王梦佳,E-mail：wangmengjia0088@sina.com
  • 作者简介:王梦佳（1986-）,女,硕士,主治医师
  • 基金资助:
    南京市医学科技发展资金 (YKK16162)

Study on the efficacy and safety of metronidazole combined with periodontal tissue regeneration in the treatment of periodontitis

WANG Meng-jia1, DA Yu2, ZHENG Li-chun3   

  1. 1. Department of Stomatology, Affiliated Stomatological Hospital, Medical College of Nanjing University. Nanjing 210018;
    2. Department of Stomatology,Sir Run Run Shaw Hospital of Nanjing Medical University. Nanjing 210018;
    3. Department of Prevention, Affiliated Stomatological Hospital, Medical College of Nanjing University. Nanjing 210018, Jiangsu Province, China
  • Received:2019-09-16 Revised:2019-11-13 Online:2020-06-25 Published:2020-07-29

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摘要： 目的 探讨奥硝唑联合牙周组织再生术治疗牙周炎的有效性及安全性。方法 选择2018年3月—2019年3月于南京大学医学院附属口腔医院接受治疗的牙周炎患者100例,随机分为再生治疗组、联合治疗组,每组50例,再生治疗组患者进行牙周组织再生治疗,联合治疗组患者使用奥硝唑联合牙周组织再生术进行治疗。对2组患者牙周相关指标牙周探诊深度（periodontal probing depth,PPD）、牙周附着水平（periodontal attachment level,PAL）、牙松动度（tooth mobility degree,MD）进行检测,对2组患者治疗前、后血清丙二醛（malondialdehyde,MDA）、超氧化物歧化酶（superoxide dismutase,SOD）、谷胱甘肽过氧化物酶（glutathione peroxidase,GSH-Px）、白细胞介素10（interleukin-10,IL-10）、白细胞介素4（interleukin-4,IL-4）、C反应蛋白（c-reactive protein,CRP）水平及免疫球蛋白水平进行检测,对比2组患者治疗效果及并发症发生情况。采用SPSS 21.0软件包对数据进行统计学分析。结果 联合治疗组患者治疗后PPD、PAL及MD水平显著低于再生治疗组（P<0.05）;联合治疗组患者血清MDA水平显著低于再生治疗组,SOD、GSH-Px水平显著高于再生治疗组（P<0.05）;联合治疗组患者血清IgA、IgM、IgG、IgE、IL-10、IL-4、CRP水平显著低于再生治疗组（P<0.05）;联合治疗组患者治疗总有效率显著高于再生治疗组,并发症发生率显著低于再生治疗组（P<0.05）。结论 使用奥硝唑联合牙周组织再生术能显著改善牙周炎患者相关牙周指数水平,减轻患者氧化应激损伤,提升患者免疫功能,抑制炎症反应,治疗效果显著,且安全性较高。

关键词: 奥硝唑, 牙周组织再生, 牙周炎, 炎症反应

Abstract: PURPOSE: To explore the efficacy and safety of ornidazole combined with periodontal tissue regeneration in the treatment of periodontitis. METHODS: From March 2018 to March 2019, 100 patients with periodontitis who received treatment in the Stomatological Hospital Affiliated to the School of Medicine of Nanjing University were selected and randomly divided into the regeneration group and combined treatment group with 50 patients in each group. Patients in the regeneration group received periodontal tissue regeneration treatment, while patients in the combined treatment group received ornidazole combined periodontal tissue regeneration treatment. Related periodontal indexes including periodontal probing depth(PPD), periodontal attachment level(PAL), tooth mobility degree(MD) were measured, serum malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (gsh-px) and interleukin 10 (IL-10) and interleukin 4 (IL-4), c-reactive protein(CRP) level and immune globulin level were detected before and after treatment, the therapeutic effects and complications were recorded and compared. SPSS 21.0 software package was used for statistical analysis of the data. RESULTS: After treatment, PPD, PAL and MD levels in the combined treatment groups were significantly lower than those in the regenerative group (P<0.05). Serum MDA level in the combined treatment group was significantly lower than that in the regenerative group, SOD and gsh-px levels were significantly higher than that in the regenerative group(P<0.05). The serum levels of IgA, IgM, IgG, IgE, IL-10, IL-4 and CRP in the combined treatment group were significantly lower than those in the regenerative treatment group (P<0.05). The total effective rate of the combined treatment group was significantly higher than that of the regenerative treatment group, and the incidence of complications was significantly lower than that of the regenerative group(P<0.05). CONCLUSIONS: Ornidazole combined with periodontal tissue regeneration can improve the level of periodontal index, alleviate oxidative stress injury, improve immune function, inhibit inflammation, and has a significant therapeutic effect with high safety.

Key words: Ornidazole, Periodontal tissue regeneration, Periodontitis, Inflammatory reaction

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