上海口腔医学

上海口腔医学 ›› 2020, Vol. 29 ›› Issue (2): 217-220.doi: 10.19439/j.sjos.2020.02.020

• 论著 • 上一篇    下一篇

口腔种植修复术在牙列缺损患者中的应用效果及对龈沟液中TNF-α、IL-6水平的影响

常忠福1, 姜丹丹1, 张志荣2, 蔡建英1   

  1. 1.上海市浦东新区人民医院 口腔科;
    2.血液净化中心,上海 201299
  • 收稿日期:2019-12-03 修回日期:2020-01-02 出版日期:2020-04-25 发布日期:2020-04-30
  • 通讯作者: 常忠福,E-mail:czf315@126.com
  • 作者简介:常忠福(1970-),男,硕士,主治医师

Effect of oral implant restoration on dentition defect patients and its impact on TNF-α and IL-6 levels in gingival crevicular fluid

CHANG Zhong-fu1, JIANG Dan-dan1, ZHANG Zhi-rong2, CAI Jian-ying1   

  1. 1.Department of Stomatology;
    2.Blood Purification Center, People's Hospital of Shanghai Pudong District. Shanghai 201299, China
  • Received:2019-12-03 Revised:2020-01-02 Online:2020-04-25 Published:2020-04-30

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摘要： 目的 探讨口腔种植修复术对牙列缺损患者的治疗效果及对龈沟液中肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、白细胞介素6(interleukin-6,IL-6)水平的影响。方法 选择2017年5月—2019年8月上海市浦东新区人民医院口腔科收治的84例牙列缺损患者,随机分为对照组(n=42)和实验组(n=42)。对照组采用常规修复方法,实验组采用口腔种植修复术治疗。治疗后6个月对疗效进行评估,比较2组患者龈沟液中TNF-α、IL-6水平,种植牙功能及并发症发生率。采用SPSS 18.0软件包对数据进行统计学分析。结果 实验组与对照组治疗后6个月TNF-α、IL-6水平显著高于治疗前(P<0.05);实验组治疗后6个月TNF-α、IL-6水平显著低于对照组(P<0.05);实验组与对照组治疗后6个月种植牙功能各项评分均显著高于治疗前(P<0.05);实验组治疗后6个月固位功能、语言功能、咀嚼功能及美观功能评分均显著高于对照组(P<0.05);实验组治疗过程中感染、刺痛感、核桩脱落、牙缺失发生率显著低于对照组(P<0.05)。结论 口腔种植修复术对牙列缺损患者龈沟液中的TNF-α、IL-6水平影响较小,种植牙功能提高,术后并发症发生率降低,值得临床推广应用。

关键词: 口腔种植修复术, 牙列缺损, 龈沟液, 肿瘤坏死因子α, 白细胞介素6

Abstract: PURPOSE: To investigate the clinical effects of oral implant restoration in patients with dentition defects and the its impact on tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) levels in gingival crevicular fluid. METHODS: Eighty-four patients with dentition defects from May 2017 to August 1919 in People's Hospital of Shanghai Pudong District were enrolled and randomly divided into control group (n=42) and experimental group (n=42). Patients in the control group were repaired by routine methods,while those in the experimental group were treated with oral implant restoration. The effect of restoration was evaluated 6 months after treatment. The levels of TNF-α, IL-6 in the gingival crevicular fluid and dental function were compared between the 2 groups. The data were analyzed using SPSS 18.0 software package. RESULTS: The levels of TNF-α and IL-6 in the experimental group and the control group after treatment were significantly higher than those before treatment (P<0.05). The levels of TNF-α and IL-6 in the experimental group were significantly lower than those in the control group 6 months after treatment (P<0.05). The scores of dental function in the experimental group and the control group were significantly higher than those before treatment (P<0.05). The scores of retention, speech, chewing and aesthetics of the experimental group 6 months after treatment were significantly higher than the control group (P<0.05). The incidence of infection, pricking, post and core loosing and teeth missing in the experimental group was significantly lower than that of the control group (P<0.05). CONCLUSIONS: In the treatment of patients with dentition defects, implant restoration has little effect on the levels of TNF-α and IL-6 in gingival crevicular fluid, which is helpful to improve dental function and reduce the incidence of postoperative complications. Therefore, it is worthwhile to be popularized in clinical application.

Key words: Oral implant restoration, Dentition defect, Gingival crevicular fluid, Tumor necrosis factor-α, Interleukin-6

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