上海口腔医学

上海口腔医学 ›› 2020, Vol. 29 ›› Issue (1): 97-101.doi: 10.19439/j.sjos.2020.01.020

• 论著 • 上一篇    下一篇

SFRP1蛋白、MIF在重度牙周炎老年患者中的表达及与认知功能的相关性分析

杜锐1, 李隽2, 吴迎涛1   

  1. 1.青岛市口腔医院 牙周病科, 山东 青岛 266000;
    2.湖南中医药高等专科学校附属第一医院 口腔科,湖南 株洲 412000
  • 收稿日期:2019-09-02 出版日期:2020-02-25 发布日期:2020-03-09
  • 通讯作者: 吴迎涛,E-mail：347107303@qq.com
  • 作者简介:杜锐（1985-）,女,硕士,E-mail：xkoihj@163.com

Expression of SFRP1 and MIF in elderly patients with severe periodontitis and its correlation with cognitive function

DU Rui1, LI Juan2, WU Ying-tao1   

  1. 1.Department of Periodontics, Qingdao Stomatological Hospital. Qingdao 266000, Shangdong Province;
    2.Department of Stomatology, the First Affiliated Hospital of Hunan College of Traditional Chinese Medicine. Zhuzhou 421000, Hunan Province, China
  • Received:2019-09-02 Online:2020-02-25 Published:2020-03-09

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摘要： 目的：探讨分泌型卷曲蛋白1（secretory crimp protein 1,SFRP1）、巨噬细胞迁移抑制因子（macrophage migration inhibition factor,MIF）在重度牙周炎老年患者中的表达及与认知功能的相关性。方法：以2018年2月—2019年2月青岛市口腔医院收治的52例老年牙周炎患者作为研究对象,根据病情严重程度,将患者分为重度牙周炎组和轻度牙周炎组。统一进行牙周检查及蒙特利尔认知评估量表（Montreal cognitive assessment,MoCA）评分后,比较2组患者血清中SFRP1和MIF水平,分析血清中SFRP1与MIF相关性及其与牙周指标及认知功能的相关性。采用SPSS 20.0软件包对数据进行统计学分析。结果：2组患者探诊深度（probing depth,PD）、临床附着水平（clinical attachment level,CAL）、龈沟出血指数（sulcus bleeding index,SBI）及龈沟液（gingival crevicular fluid,GCF）均有显著差异（P<0.05）;重度牙周炎组患者血清中SFRP1与MIF水平显著高于轻度牙周炎组（P<0.05）;血清中SFRP1水平与MIF呈正相关（P<0.05）;血清中SFRP1及MIF水平与牙周指标均呈正相关（P<0.05）;重度牙周炎组患者MoCA评分显著低于轻度牙周炎组（P<0.05）;血清中SFRP1及MIF水平均与MoCA评分呈负相关（P<0.05）。结论：老年牙周炎患者血清中SFRP1与MIF均呈高表达状态,且随牙周破坏程度的加重,水平逐渐上升。牙周炎患者可出现一定程度的认知功能障碍,SFRP1与MIF可能参与牙周炎患者认知功能障碍的发生与发展。

关键词: SFRP1, MIF, 重度牙周炎, 认知功能, 相关性

Abstract: PURPOSE: To investigate the expression of secreted frizzle-related protein 1 (SFRP1) and macrophage migration inhibitory factor (MIF) in elderly patients with severe periodontitis and its correlation with cognitive function. METHODS: Thirty-two elderly patients with periodontitis in Qingdao Stomatological Hospital from February 2018 to February 2019 were enrolled, and divided into two groups according to the severity: mild group and severe group. All selected subjects received periodontal examination and Montreal cognitive assessment (MoCA).The expression of SFRP1 and MIF in serum was also determined. Then the correlations among SFRP1 and MIF periodontal index and cognitive function was analyzed. The data were processed by SPSS 20.0 software package. RESULTS: The probing depth (PD), clinical attachment level (CAL), sulcus bleeding index (SBI) and gingival crevicular fluid (GCF) showed significant difference between the two groups (P<; 0.05). The serum levels of SFRP1 and MIF in the severe group were significantly higher than those in the mild group (P<; 0.05). Serum SFRP1 level was positively correlated with MIF (P<; 0.05). Serum SFRP1 and MIF levels were positively correlated with periodontal index (P<; 0.05). The MoCA score of the severe group was significantly lower than that of the mild group (P<; 0.05). Serum SFRP1 and MIF levels were negatively correlated with MoCA score (P<; 0.05). CONCLUSIONS: SFRP1 and MIF are highly expressed in serum and gingival tissues of elderly patients with severe periodontitis, and are closely related to the degree of periodontal damage. Meanwhile, patients with periodontitis may have some degree of cognitive dysfunction, and SFRP1 and MIF may affect the periodontal tissue structure through Wnt/β-catenin signal pathway and participate in the occurrence and development of cognitive dysfunction.

Key words: SFRP1, MIF, Severe periodontitis, Cognitive function, Correlation

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