增强CT对头颈部鳞癌患者颈部淋巴结包膜外侵犯的诊断效能：系统评价与meta分析

doi:10.19439/j.sjos.2018.06.023

上海口腔医学 ›› 2018, Vol. 27 ›› Issue (6): 668-672.doi: 10.19439/j.sjos.2018.06.023

• 系统评价 • 上一篇

增强CT对头颈部鳞癌患者颈部淋巴结包膜外侵犯的诊断效能：系统评价与meta分析

唐曹敏^1,2, 乔翔鹤^1,2, 李春洁^1,2,*, 闫恺潇^1,2, 林洁², 王晓毅^1,2,*

1.四川大学华西口腔医学院头颈肿瘤外科,四川成都 610041;
2.口腔疾病国家重点实验室,四川成都 610041

收稿日期:2017-06-13 出版日期:2018-12-25 发布日期:2019-01-11
通讯作者: 李春洁, E-mail: lichunjie@scu.edu.cn;王晓毅,E-mail: wxyz711@163.com。^*共同通信作者
作者简介:唐曹敏（1991-）,男,博士研究生,E-mail: 619897077@qq.com

Contrast-enhanced CT for the diagnosis of extracapsular spread by head and neck cancers: a systematic review and meta analysis

TANG Cao-min^1,2, QIAO Xiang-he^1,2, LI Chun-jie^1,2, YAN Kai-xiao^1,2, LIN Jie², WANG Xiao-yi^1,2

1.Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University. Chengdu 610041;
2. State Key Laboratory of Oral Disease, Sichuan University. Chengdu 610041, Sichuan Province, China

Received:2017-06-13 Online:2018-12-25 Published:2019-01-11
Supported by:
2016年四川大学优秀青年学者基金（2082604194311）; 2017年四川大学青年教师科研启动基金（2017SCU11009）

摘要/Abstract

摘要： 目的: 评价增强CT对头颈部鳞癌患者颈部淋巴结包膜外侵犯的诊断效能。方法: 根据预先设定的检索式,对PubMed、EMBASE、中国生物医学文献数据库（Chinese Biomedical Literature Database）以及CNKI等数据库进行电子检索,并在SciencePaper Online上搜索尚未正式发表的文献,检索时间截至2017年5月15日;同时进行手工检索。2名评价者独立使用QUADAS-2,评价纳入研究的方法学质量并进行数据提取。运用MetaDisc 1.4、STATA 11.0软件进行meta分析。结果: 最终纳入8篇文献,涉及患者639例。8篇均为回顾性研究,1篇有高偏倚风险,其余偏倚风险情况不清。Meta分析结果显示,增强CT在诊断淋巴结包膜外侵犯的合并敏感度为0.67,合并特异度为0.84,曲线下面积为0.83。结论: 增强CT可作为头颈部鳞癌患者颈部淋巴结包膜外侵犯的确诊工具。

关键词: 头颈癌, 淋巴转移, 包膜外侵犯, 系统评价, 诊断性试验, Meta分析

Abstract: PURPOSE: This study aimed to assess the diagnostic efficacy of contrast-enhanced CT in the screening of extracapsular spread by head and neck cancers. METHODS: Electronic databases, including MEDLINE, EMBASE,CBM,CNKI and SciencePaper Online were searched electronically. Hand-searching was also performed. QUADAS-2 was used by two independent reviewers to assess the methodological quality, and data extraction of included studies was delivered. Meta analysis was conducted via MetaDisc1.4 and STATA 11.0. RESULTS: A total of 8 studies involving 639 participants were included. All studies were retrospective, 1 had high risk of bias, and the remaining had unclear risk of bias. Meta analysis showed that when screening extracapsular spread, contrast-enhanced CT had a pooled sensitivity of 0.67, pooled specificity of 0.84, area under curve of 0.83. CONCLUSIONS: Contrast-enhanced CT is a good tool for diagnosing extracapsular spread by head and neck cancers.

Key words: Head and neck cancers, Lymphatic metastasis, Extracapsular spread, Systematic review, Diagnostic test, Meta analysis

中图分类号:

R739.8

唐曹敏, 乔翔鹤, 李春洁, 闫恺潇, 林洁, 王晓毅. 增强CT对头颈部鳞癌患者颈部淋巴结包膜外侵犯的诊断效能：系统评价与meta分析[J]. 上海口腔医学, 2018, 27(6): 668-672.

TANG Cao-min, QIAO Xiang-he, LI Chun-jie, YAN Kai-xiao, LIN Jie, WANG Xiao-yi. Contrast-enhanced CT for the diagnosis of extracapsular spread by head and neck cancers: a systematic review and meta analysis[J]. Shanghai Journal of Stomatology, 2018, 27(6): 668-672.

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增强CT对头颈部鳞癌患者颈部淋巴结包膜外侵犯的诊断效能：系统评价与meta分析

Contrast-enhanced CT for the diagnosis of extracapsular spread by head and neck cancers: a systematic review and meta analysis

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